Dr Carolyn Shembrey

Postdoctoral Researcher, Peter Maccallum Cancer Centre

Carolyn is a postdoctoral researcher working on oncogene-directed mRNA therapeutics at the Peter MacCallum Cancer Centre. She completed her PhD in 2021 at The University of Melbourne Centre for Cancer Research, where she interrogated the landscape of NK cell activity in metastatic colorectal cancer using a suite of multidisciplinary approaches, including patient-derived organoid models, multiplex immunohistochemistry and extensive bioinformatics analysis.

Her current research focusses on engineering novel CRISPR-based molecular tools that selectively ablate oncogenic transcripts, with a particular emphasis on targeting single nucleotide variants (SNVs) at the RNA level. Her ongoing research goal is to apply these cutting-edge CRISPR technologies to target undruggable oncogenic targets, including SNVs and gene fusion transcripts, to provide an innovative therapeutic modality for cancer patients.